Pfizer Animal Health

Get more information about a specific species.


SLENTROL®
dirlotapide
Oral Solution for dogs

Description

Introducing the first proven and dependable veterinary medication for the management of canine obesity.

  • SLENTROL (dirlotapide) is a solution formulated at a concentration of 5 mg/mL of dirlotapide for oral administration of dogs. Dirlotapide is a selective microsomal triglyceride transfer protein inhibitor that blocks the assembly and release of lipoprotein particles into the bloodstream (via the lymphatic system) in dogs.1
Watch How it works


Approved Uses

SLENTROL® is indicated for the management of obesity in dogs.

Key Features

Used as directed, SLENTROL®
  • Provides a medically appropriate approach to weight management for obese dogs
  • Achieves and helps maintain weight loss with 2 phases of medication
  • Offers a convenient, once-daily dose that can be used with any nutritionally complete diet

Packaging
  • SLENTROL® is available in 20mL, 50mL, and 150mL bottles with easy to use calibrated oral dosing syringes.

Dosage and Administration

SLENTROL should be prescribed as part of an overall weight management program that incorporates a complete and balanced canine diet and physical activity. The dog will need to be weighed at the start of treatment and then at monthly intervals so that the dosing regimen can be adjusted according to the prescribing instructions below:

During the first month of therapy, the dosing regimen for SLENTROL consists of two fixed dose rates (number of mL administered per unit of body weight) in all dogs. In subsequent months of therapy, the recommended dosing regimen prescribed for SLENTROL varies for each individual dog and the dose volume must be specifically calculated each month, based on the amount of weight lost (expressed as a percent) during the previous month of therapy.

With regard to dosing it is important to note that:
  • Initial body weight is used to calculate the dose that is first administered.
  • Subsequent dose adjustments are made by adjusting the volume of solution administered.
  • Dose adjustments are determined by your veterinarian at monthly intervals at your dogs's monthly recheck.
The dose should not exceed a maximum daily dose of 0.2 mL/kg (0.09 mL/lb), based on the dog's current body weight, during any part of treatment.


Contraindications

SLENTROL should not be used in cats. SLENTROL increases the risk of producing hepatic lipidosis during weight loss in obese cats. SLENTROL is not recommended for use in dogs currently receiving long-term corticosteroid therapy. Do not use in dogs with liver disease.

WARNINGS: Not for use in humans. Keep this and all drugs out of reach of children. Adverse reactions associated with humans ingesting dirlotapide include: abdominal distention, abdominal pain, diarrhea, flatulence, headache, increased serum transaminases, nausea, and vomiting.

SLENTROL may cause eye-irritation. If accidental eye exposure occurs, flush the eyes immediately with clean water.


Precautions
  • SLENTROL has not been evaluated in dogs less than 1 year of age.
  • Safety in breeding, pregnant, or lactating dogs has not been established. Caution should be taken when considering any weight loss program in growing dogs, including treatment with SLENTROL.
  • All dogs should undergo a thorough history and physical examination that includes laboratory tests to screen for underlying conditions. Pre-existing endocrine disease, including hyperadrenalcorticalism (Cushing's disease), should be managed prior to use of SLENTROL.

Caution

  • Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.
  • Store in original container at room temperature 15° to 30° C (59° to 86° F).

Reference
  1. Wetterau, J.R. Microsomal triglyceride transfer protein: role in the assembly of intestinal lipoproteins. Intest. Lipid Metab. 2001; 171-184. Kluwer Academic/Plenum Publishers, New York, N.Y.
Additional Information

Check back soon to see the expanded Slentrol website for Pet Owners.

www.slentrol.com
www.stopcanineobesity.com
SLENTROL Owner Information
Keeping Your Dog Healthy Brochure

Product Information

Back to top
entire article (printer friendly)
PfizerAH Dogs Home
Locate a Product

Use the menus below to find product information.

 View all PfizerAH Dog products

Locate a Product

There are no scheduled
events listed at this time.

Search
 
Advanced Search

Visit only4vets



Copyright © 2008 Pfizer Inc. All rights reserved.


The product information provided in this site is intended only for residents of the United States. The products discussed herein may have different product labeling in different countries.

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.