TRITOP®(neomycin sulfate, isoflupredone acetate and tetracaine hydrochloride)
Topical Ointment
The Power of Three
Indications
TRITOP® Topical Ointment is indicated as treatment or adjunctive therapy for certain ear and skin conditions caused by or associated with neomycin-susceptible organisms and/or allergy. In addition, it is indicated as superficial dressing applied to minor cuts, wounds, lacerations and abrasions, and for post-surgical application where reduction of pain and inflammatory response is deemed desirable.
TRITOP Topical Ointment is a useful dressing for minor cuts, lacerations, abrasions, and post-surgical
therapy. It may also be used after amputation of dewclaws, tails and claws, and after ear trimming and castrating operations.
Key Features
- TRITOP Topical Ointment contains the potent anti-inflammatory agent isoflupredone acetate 1 mg (0.1%); the antibiotic neomycin sulfate, 5 mg (0.5%) (equivalent to 3.5 mg neomycin); and the topical anesthetic tetracaine hydrochloride, 5 mg (0.5%). This combination is well suited for the treatment or adjunctive therapy of many ear and skin conditions, as well as a dressing for superficial wounds. Its action is specific as to anti-inflammatory, bactericidal and anesthetic properties.
- Neomycin is a broad-spectrum antibiotic. Its antimicrobial range includes both gram-positive and
gram-negative organisms commonly responsible for or associated with otic infections, such as
staphylococci, streptococci, Escherichia coli, Aerobacter aerogenes, and many strains
of Proteus and Pseudomonas organisms. Neomycin is unusually nontoxic for epithelial
cells in tissue culture and is nonirritating in therapeutic concentrations.
- Tetracaine hydrochloride is a topical anesthetic agent that is more potent than procaine
in comparable concentrations and has greater ability than procaine to penetrate mucous
membranes. The duration of anesthetic action of tetracaine exceeds that produced by either butacaine
or phenacaine.
- Many investigators have demonstrated that local anesthesia plays a significant part in the promotion of healing, especially where pain is a prominent factor. It is believed that trauma stimulates local pain receptors, resulting in reflex vasodilation, edema, tenderness and muscular spasm.
- If the reflex is abolished through use of a local anesthetic such as tetracaine, amelioration of
tissue changes that interfere with healing is favored. The local anesthetic action of tetracaine has
proved to be of great value in alleviating the pain reflex in painful skin and ear conditions.
Packaging
10-g tubes with a special applicator tip
Dosage/Administration
To treat otitis externa and other inflammatory conditions of the external ear canal, fill the external ear canal with ointment 1 to 3 times daily. To use on the skin or mucous membranes, cleanse the affected area, apply a small amount of the ointment, and spread or rub it in gently. The involved area may be treated 1 to 3 times a day and these daily applications continued in accordance with the clinical response. Limit treatment to the period when local anesthesia is essential to control self-inflicted trauma.
Avoid use of this product with ruptured tympanic membranes. If hearing or balance is affected during treatment, discontinue use.
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Product Information
Material Safety Data Sheet
Back to top
entire article (printer friendly)
