Description

• DEFENSOR^® 3 contains chemically inactivated rabies virus prepared from cell culture. The seed virus is a highly immunogenic, fixed strain of rabies virus that originated from Louis Pasteur’s original 1882 isolate. The inactivated virus is formulated with a highly purified adjuvant and is packaged in liquid form. Following primary vaccination, DEFENSOR 3 is approved for revaccination of dogs every 3 years with a single dose.



• DEFENSOR 3 produced for sale in California meets specific potency standards required by that state.

• Vaccination of healthy dogs 3 months of age or older as an aid in preventing rabies.

• DEFENSOR 3 is exceptionally well-tolerated after injection, due to a purified adjuvant and a novel dual-buffering system that restricts pH to a narrow, safe range.



• Studies conducted in mice to evaluate the relative effective dose of DEFENSOR 3 versus a CDC reference virus against 5 wild rabies viruses indicated that vaccine effectiveness extends beyond canine isolates to include naturally occurring wildlife strains, with protection against raccoon and bat rabies virus isolates.



• Customer-friendly packaging using recycled materials includes peel-off labels to make record-keeping faster and more accurate, a color-coded organizing system, and an easy-open safety band.

• General directions: Shake well. Aseptically administer 1 mL subcutaneously. Dogs may be vaccinated intramuscularly or subcutaneously.



• Primary vaccination: Administer a single dose at 3 months of age or older to healthy dogs. A repeat dose should be given 1 year later.



• Revaccination: Subsequent revaccination every 3 years with a single dose is recommended.

• Store at 2°– 7° C. Prolonged exposure to higher temperature may adversely affect potency. Do not freeze. Use entire contents when first opened. Sterilized syringes and needles should be used to administer this vaccine. Burn containers and all unused contents.



• As with many vaccines, anaphylaxis may occur after use. Initial antidote of epinephrine is recommended and should be followed with appropriate supportive therapy.



• DEFENSOR 3 has been shown to be efficacious in healthy animals. A protective immune response may not develop if animals are incubating an infectious disease, are malnourished or parasitized, are stressed due to shipment or environmental conditions, are otherwise immunocompromised, or if the vaccine is not administered according to label directions.



• For veterinary use only.